The report, which was published in the “Lancet” medical journal, stated that everyone who took the vaccine developed antibodies to fight the virus, without experiencing any serious side effects.
Russia granted the license to use the vaccine domestically in August, being the first country to take this step.
Experts say the trials were too small to prove their effectiveness and safety, but Moscow praised the results in response to criticism.
Some Western experts expressed concern about the speed of the Russians ’work, and suggested that researchers had shortened the way during their work.
What was stated in the report?
The “Lancet” reported that two vaccine trials took place between June and July, in which 38 healthy volunteers, aged between 18 and 60 years, participated in each of them. They were given a dose of the vaccine, followed by another dose three weeks later. The participants were monitored within 42 days, and all developed antibodies within three weeks.
The report stated that “there is a need for large and long-term trials that include more monitoring to prove the safety and effectiveness of the vaccine in the long term to prevent Covid-19 infection.”
The magazine reported that the third phase of the exams will include 40,000 volunteers from “different age groups and groups at risk of (health) risks.”
The Russian vaccine uses modified strains of the adenovirus, which usually causes the common cold, to stimulate an immune response.
Is it safe?
The magazine mentioned that all adenovirus-based vaccines are safe, even with high doses, so the “Sputnik V” vaccine is safe for people between the ages of 18 – 60 years, but she wondered whether it really protects against “Corona”.
The Russian experiments showed that the vaccine stimulates high levels of antibodies that can stick to the communication protein in the emerging virus, but the most important measure is the level of antibodies that work, and can the antibodies prevent or neutralize the virus? Which is not answered by the results.
The journal indicated that antibody levels are very low in this study, compared to trials of other published vaccines. So are the responses of T cells (the other arm of the immune system to fight the virus).
She emphasized that in the absence of international reference standards, it is not possible to know whether this vaccine is better or worse compared to the others. The magazine added that it is difficult to determine if this level of neutralization for the virus provided by the vaccine is sufficient to protect against infection, and it is difficult to determine how long these antibodies remain in the blood, as the experiments show results after only one month.
Is it ready for use?
The magazine stated that despite the positive results of a small trial of the first phase of the Sputnik vaccine, it must be tested on a much larger group of people before it is used and given to people. And she stressed the need to test all vaccines on large numbers of people, of different ages and races, in the third phase of clinical trials, adding that the third phase trials are necessary to gain a high level of confidence that the vaccine protects against infection, and it also helps to get rid of side effects Rare that may not appear in a small group of healthy volunteers.
Proof of potency
In a related context, the “Wall Street Journal” newspaper reported that a number of companies developing vaccines, including “Pfizer”, “Johnson & Johnson” and “Moderna”, intend to issue a general commitment not to seek government approval for their products before it is proven that they are safe and effective. .
The newspaper’s report added that the pledge could be issued soon, perhaps this week.
This comes amid growing concern that political pressures ahead of the US elections on the 3rd of November will affect the safety and efficacy of any potential vaccine for this respiratory disease.
The White House said that there is no political pressure on the United States health regulator to quickly approve a vaccine.
And the companies «Astrazhinica», «Pizer» and «Moderna» are among the companies that are at the forefront of the race to develop vaccines, as their vaccines are in the final stages of clinical trials.
In turn, Johnson & Johnson revealed that it had successfully developed a vaccine that had proven effective in mice. The company said that the hamster was vaccinated with the vaccine before being exposed to the new Corona, and after about four weeks, scientists noticed a decrease in the infection in the lungs of the hamster rat.
For its part, new studies conducted by the World Health Organization have shown that people who suffer from non-communicable diseases are more likely to die if infected with Corona, according to the “Voice of America” website.
The organization says that seven out of 10 deaths worldwide are caused by cardiovascular disease, cancer, diabetes, respiratory system and other non-communicable diseases.
Of these, the data indicates that 17 million people die prematurely, and the vast majority of them are between the ages of 30 and 70.
A possible natural inhibitor against the virus
, a new scientific study revealed an inhibitor that may actually succeed in limiting the activity and spread of Corona, extracted from a substance produced by nature.
In a report published by the Italian “Aki” agency, the NATO Technology Institute of the National Research Council in Italy said: Quercetin showed abilities of natural origin in limiting the spread of the virus. The study reported that “quercetin, a compound of natural origin, acts as a specific inhibitor of corona movement, and it is a substance that actually shows destabilizing activity of 3CLpro, which is one of the main proteins of the pathogen.”
“Quercetin, by blocking the enzymatic activity of 3CLpro, kills SARS-CoV-2,” the study said.
Expectations of two million deaths in the coming months
A report published by the British newspaper The Independent revealed yesterday that the Institute for Health Metrics and Evaluation at the College of Medicine at the University of Washington concluded, through a statistical model, that deaths related to the Corona virus could increase three times by the end of this year to reach To 1.9 million people, mostly in Europe, Central Asia, and the United States.
He stated that the total death toll could reach 2.8 million by January 1, 2021, unless governments consider relaxing measures designed to undermine the spread of the virus.
“We are facing the possibility that December 2020 will be a deadly month, especially in Europe, Central Asia and the United States,” said Christopher Murray, director of the Institute for Health Metrics and Evaluation. But the science is clear, and the evidence cannot be disproved: wearing masks, social distancing and identifying social gatherings are vital to help prevent transmission of the virus.
On the other hand, the English actor Robert Pattinson was infected with “Corona”, which led to the suspension of filming of his new movie, “The Batman.” The “Hollywood Reporter” website said that the producer, “Warner Brothers,” reported that a member of the film crew was injured without revealing his identity.
“Vanity Fire” magazine and the “Hollywood Reporter” website quoted sources close to the film crew that the person who was injured was Robert Pattinson.